A dual role for acetohydrazide in Pd-catalyzed controlled C(sp3)–H acetoxylation of aldehydes

Autor:	Yong-Sheng Bao, Dan Liu, XingWen Tong, Chaolumen Bai, Juan Chen
Rok vydání:	2020
Předmět:	chemistry.chemical_classification chemistry.chemical_compound Dual role Chemistry General Chemical Engineering Functional group chemistry.chemical_element General Chemistry Protecting group Medicinal chemistry Aldehyde Palladium Catalysis
Zdroj:	RSC Advances. 10:12192-12196
ISSN:	2046-2069
DOI:	10.1039/d0ra01927e
Popis:	The palladium catalyzed aldehyde directed acetoxylation of C(sp3)–H bonds was realized by a transient directing group approach for the first time. Crucial to the successful outcome of this reaction is the dual role of acetohydrazide as a directing group for the catalytic C(sp3)–H activation process and as a protecting group for the CHO functional group. The applicable methodology exhibits good functional group tolerance and occurs readily under mild conditions.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::0328bbfdd67d007b82bbf2c7bbc14a09 https://doi.org/10.1039/d0ra01927e Zobrazit plný text záznamu