Ultrastructural changes associated with carbon tetrachloride hepatotoxicity in channel catfish, Ictalurus punctatus Rafinesque
| Autor: | S. H. Afifi, J. R. MacMILLAN |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
medicine.medical_specialty
biology Veterinary (miscellaneous) Endoplasmic reticulum CCL4 Vacuole Aquatic Science biology.organism_classification medicine.disease Molecular biology chemistry.chemical_compound Endocrinology chemistry Ictalurus Internal medicine medicine Carbon tetrachloride Ultrastructure Cell damage Catfish |
| Zdroj: | Journal of Fish Diseases. 15:119-129 |
| ISSN: | 1365-2761 0140-7775 |
| DOI: | 10.1111/j.1365-2761.1992.tb00646.x |
| Popis: | Ultrastructural changes occurring in juvenile channel catfish, Ictalurus punctatus Ratinesque, hepatocytes were examined following exposure to carbon tetrachloride (CCl4). Juvenile catfish were intraperitoneally injected with a sublethal dose of undiluted CCl4and controls, used for comparisons, received physiological saline. The rough endoplasmic rcticulum (RER) was slightly dilated by 1 h and was significantly dilated by 4 and 24 h post-CCl4-exposure. At 4 h, the RER became degranulated, mitochondrial eristae indistinct with electron dense flocculant matrieal deposits, and nuclear membranes indented. Autophagic vacuoles were present in some hepatocytes. Within 48 h post-exposure, the hepatocytes were indistinguishable from control hepatocytes. CCl4 can induce reversible or irreversible cell damage which appears dose dependent. |
| Databáze: | OpenAIRE |
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