Plasticity of cerebellar granule cell precursors

Autor:	Toshiyuki Himi, Yasuki Ishizaki, Takayuki Okano-Uchida, Yoshiaki Komiya
Rok vydání:	2003
Předmět:	Cerebellum biology General Physics and Astronomy General Medicine Bone morphogenetic protein Granule cell Neural stem cell medicine.anatomical_structure CXCL3 nervous system Precursor cell medicine biology.protein Neuron Sonic hedgehog General Agricultural and Biological Sciences Neuroscience
Zdroj:	Proceedings of the Japan Academy, Series B. :223-226
ISSN:	1349-2896 0386-2208
DOI:	10.2183/pjab.79b.223
Popis:	It is generally assumed that neural stem cells give rise first to neuronal precursor cells, and that these precursor cells then proliferate extensively before terminally differentiating into postmitotic neurons. It is still not clear, however, whether the precursor cells are irreversibly determined to differentiate into neurons. In this study, we isolated immature cerebellar granule cell precursors from the developing mouse cerebellum. The immature precursors differentiated into granule cells in the absence of any signaling molecule, indicating that differentiation into neurons is the default pathway for these cells. A part of these immature neuronal precursors, however, differentiated into astrocytes when exposed to sonic hedgehog and bone morphogenetic proteins. Our results suggest that some, at least, neuronal precursor cells are not irreversibly committed to differentiating into neurons, but still have the plasticity to differentiate into astrocytes.(Communicated by Tamio YAMAKAWA, M. J. A., Sept. 12, 2003)
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::03231f475dbadd967329e0b8fa8a3308 https://doi.org/10.2183/pjab.79b.223 Zobrazit plný text záznamu