Resolution of 1-cyclohexylethylamine via diastereomeric salt formation with enantiopure 2-phenylacetic acids
| Autor: | Kenichi Sakai, Masami Yokoyama, Noriaki Hirayama, Rumiko Sakurai |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
chemistry.chemical_classification
Diastereomeric recrystallization Resolution (mass spectrometry) Stereochemistry Organic Chemistry Diastereomer Salt (chemistry) Catalysis Inorganic Chemistry Enantiopure drug chemistry Cyclohexylethylamine Organic chemistry Physical and Theoretical Chemistry Enantiomer Salt formation |
| Zdroj: | Tetrahedron: Asymmetry. 17:1541-1543 |
| ISSN: | 0957-4166 |
| DOI: | 10.1016/j.tetasy.2006.05.010 |
| Popis: | The resolution of 1-cyclohexylethylamine 1 with enantiopure 2-phenylacetic acids via diastereomeric salt formation was investigated. ( R )-2-Methoxy-2-phenylacetic acid 3 and the ( S )-2-phenylpropionic acid 5 were found to be efficient resolving agents for obtaining the single enantiomer ( S )- 1 as the correspondingly less-soluble diastereomeric salt (resolution efficiency = 48% and 52%, respectively). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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