Atropine inhibition of the cardiodepressive effect of mono(2-ethylhexyl)phthalate on human myocardium*1

Autor:	Monika Tocchi, Wilbert J. Keon, Rosalind S. Labow, Yvonne A. Barry
Rok vydání:	1990
Předmět:	Pharmacology endocrine system business.industry Stereochemistry Metabolite Plasticizer Phthalate Toxicology Atropine chemistry.chemical_compound Dose–response relationship chemistry Mechanism of action Toxicity Medicine medicine.symptom business Receptor medicine.drug
Zdroj:	Toxicology and Applied Pharmacology. 106:48-52
ISSN:	0041-008X
Popis:	Di(2-ethylhexyl)phthalate (DEHP) is a commonly used plasticizer in polyvinylchloride (PVC)-derived plastic. Mono(2-ethylhexyl)phthalate (MEHP), the major metabolite of DEHP, had a reversible, concentration-dependent (15-200 micrograms/ml) negative inotropic effect on a human in vitro atrial trabecular isometric preparation with an IC50 of 85 micrograms/ml. When atropine (22-32 micrograms/ml) was included in the atrial preparation the IC50 was shifted to greater than 120 micrograms/ml, suggesting that MEHP acts in part through the cholinergic receptors.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::031e3ca0bb1dc76af67c7126d6bd77df https://doi.org/10.1016/0041-008x(90)90104-3 Zobrazit plný text záznamu