Biodistribution of iron-oxide-stabilized 99mTc- ZrO2 nanoparticles in rabbit using honey as a capping agent—microwave-assisted sol–gel approach
| Autor: | Amreen Qamar, Shahzad Naseem, Tanzeela Batool, Saira Riaz, Abubaker Shahid, Irfan Ullah Khan, Rizwana Zahoor, Muhammad Imran |
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| Rok vydání: | 2021 |
| Předmět: |
Biodistribution
Materials science Iron oxide Nanoparticle 02 engineering and technology General Chemistry 010402 general chemistry 021001 nanoscience & nanotechnology Condensed Matter Physics 01 natural sciences 0104 chemical sciences Electronic Optical and Magnetic Materials Biomaterials Tetragonal crystal system chemistry.chemical_compound chemistry Materials Chemistry Ceramics and Composites Cubic zirconia Crystallite 0210 nano-technology Nuclear chemistry Superparamagnetism Sol-gel |
| Zdroj: | Journal of Sol-Gel Science and Technology. 98:95-112 |
| ISSN: | 1573-4846 0928-0707 |
| DOI: | 10.1007/s10971-021-05497-y |
| Popis: | One of the major biomedical problems facing worldwide is the diagnosis and treatment of tumor. This disease may lead to severe incidence with increased mortality rates. Therefore, it is the need of present era to develop advanced tools/methods for timely diagnosis of tumor. Aim of the present study is to evaluate the cytotoxicity and biodistribution of iron-oxide-stabilized zirconia (IOZH) nanoparticles with honey as a capping agent. In vivo-targeted diagnostic applications of stabilized ZrO2 nanoparticles are investigated through biodistribution of nanoparticles in rabbits. Nanoparticles (NPs) are synthesized using the microwave-assisted sol–gel method. Powers of microwave energy (100–900 W) are varied to synthesize stabilized zirconia NPs. Honey, as an organic capping agent, is added during synthesis. Structural results demonstrate the appearance of stabilized tetragonal phase of zirconia at 700 and 900 W without any further heat treatments. Smaller crystallite size of ~20 nm is observed for stabilized zirconia samples. Higher X-ray density is observed for pure tetragonal phase at 700 and 900 W. High dielectric constant (~55.8 at log f = 4) along with low tan loss is observed for zirconia prepared at 900 W. Magnetic results show superparamagnetic nature of the samples synthesized at 700 and 900 W. Radiolabeling along with biodistribution of iron-oxide-stabilized zirconia nanoparticles with technetium-99m is studied in normal rabbits. It is worth mentioning here that high-yield efficacy and stability along with its biodistribution and scintigraphy studies have been investigated. High uptake of radiotracer in bladder of rabbit is found to be potential candidate for its use in tumor therapies. Urination and physical properties of rabbit, after the post injection of nanoparticles, are checked periodically for many months and found normal. |
| Databáze: | OpenAIRE |
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