| Autor: |
Margaret Price, Gail Graham, Kevin W. Garey, Thanh Dao-Tran, Herbert L. DuPont, Zhi-Dong Jiang, Pablo C. Okhuysen, Mark LaRocco |
| Rok vydání: |
2007 |
| Předmět: |
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| Zdroj: |
Clinical Gastroenterology and Hepatology. 5:964-968 |
| ISSN: |
1542-3565 |
| DOI: |
10.1016/j.cgh.2007.04.018 |
| Popis: |
Background & Aims: Previous studies have shown that failure to produce serum antibodies to C. difficile (CD) toxin A is associated with more severe and recurrent C. difficile –associated diarrhea (CDAD); and that presence of AA genotype in the interleukin (IL)-8 gene promoter −251 position is associated with increased susceptibility to CDAD. This study examined the relationship between serum immunoglobulin G antibodies to CD toxin A and the presence of IL-8 AA genotype in hospitalized patients with CDAD. Methods: At enrollment, blood for host IL-8 genotype, serum for CD anti–toxin A antibody, and stool for IL-8 by enzyme-linked immunosorbent assay were obtained in CDAD patients and in CD-toxin–negative asymptomatic controls. Results: Nine of 24 (37.5%) CDAD and 3 of 20 (15%) controls were CD anti–toxin A positive ( P = .095). Eleven of 24 (45.8%) CDAD subjects were positive for AA genotype compared with 5 of 20 (25.0%) controls ( P = .0019). One of 11 (9.1%) CDAD with AA genotype were positive for anti–toxin A antibodies compared with 8 of 13 (61.5%) non-AA genotype CDAD ( P Conclusions: This study provided evidence that host susceptibly to C. difficile diarrhea is related both to a defective humoral immune response to CD toxin A and host IL-8 AA genotype. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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