| Autor: |
Yves Carpentier Solorio, Antoine P. Fournier, Catherine Larochelle, Hélène Jamann, Olivier Tastet, Ana Carmena Moratalla, Camille Grasmuck, Elizabeth Gowing, Madeleine Durand, Negar Farzam-Kia, Marc Charabati, Daniel Kaufmann, Victoria Hannah Mamane, Nicolas Chomont, Florent Lemaître, Jean-François Cailhier, Alexandre Prat, Rose-Marie Rébillard, Abdelali Filali-Mouhim, Audrey Daigneault, Nathalie Brassard, Karine Thai, Lyne Bourbonnière, Michaël Chassé, Renaud Balthazard, Andrés Finzi, Nathalie Arbour |
| Rok vydání: |
2020 |
| Předmět: |
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| DOI: |
10.1101/2020.12.21.20248642 |
| Popis: |
Dysregulated immune profiles have been described in symptomatic SARS-CoV-2-infected patients. Whether the reported immune alterations are specific to SARS-CoV-2 infection or also triggered by other acute illnesses remains unclear. We performed flow cytometry analysis on fresh peripheral blood from a consecutive cohort of i) patients hospitalized with acute SARS-CoV-2 infection; ii) patients of comparable age/sex hospitalized for other acute disease (SARS-CoV-2 negative); and iii) healthy controls. Using both data-driven and hypothesis-driven analyses, we found several dysregulations in immune cell subsets (e.g. decreased proportion of T cells) that are similarly associated with acute SARS-CoV-2 infection and non-COVID-19 related acute illnesses. In contrast, we identified specific differences in myeloid and lymphocyte subsets that are associated with SARS-CoV-2 status (e.g. elevated proportion of ICAM-1+mature/activated neutrophils, ALCAM+monocytes, and CD38+CD8+T cells). A subset of SARS-CoV-2-specific immune alterations correlated with disease severity, disease outcome at 30 days and mortality. Our data provides novel understanding of the immune dysregulation that are specifically associated with SARS-CoV-2 infection among acute care hospitalized patients. Our study lays the foundation for the development of specific biomarkers to stratify SARS-CoV-2+patients at risk of unfavorable outcome and uncover novel candidate molecules to investigate from a therapeutic perspective. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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