Application of phosphorescence quenching by O 2 to the investigation of O 2 delivery to ocular tissues

Autor:	Constantin J. Pournaras, Benno L. Petrig, Stéphane R. Chamot, Christine L. Percicot, Charles E. Riva, George N. Lambrou
Rok vydání:	2001
Předmět:	Retina Quenching (fluorescence) Phosphorescence quenching Chemistry Analytical chemistry Glaucoma chemistry.chemical_element Partial pressure medicine.disease Oxygen medicine.anatomical_structure Optic nerve medicine Phosphorescence Biomedical engineering
Zdroj:	SPIE Proceedings.
ISSN:	0277-786X
DOI:	10.1117/12.446498
Popis:	The technique of phosphorescence quenching by O 2 (PQ) allows the non-invasive measurement of the partial pressure of oxygen in blood (pO 2 blood ). This technique and its application to the investigation of the pO 2 blood in the microvasculature of the retina and optic nerve head (ONH) of two animal species is described. Using the imaging mode of PQ, 2-dimensional pO 2 blood maps were obtained to investigate the response of the pO 2 blood to various physiological stimuli in miniature pigs and the effect of experimental glaucoma in monkeys. Applied in its focal mode, PQ allows measurements of the pO 2 blood with a time resolution of 1 second and is adequate to investigate the pO 2 blood time course during light stimulation.
Databáze:	OpenAIRE
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