FRETting over postsynaptic PKC signaling
| Autor: | Kevin M. Woolfrey, Mark L. Dell'Acqua |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Brain-derived neurotrophic factor Dendritic spine Chemistry General Neuroscience Long-term potentiation 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Excitatory synapse Postsynaptic potential NMDA receptor Signal transduction Neuroscience 030217 neurology & neurosurgery Protein kinase C |
| Zdroj: | Nature Neuroscience. 21:1021-1022 |
| ISSN: | 1546-1726 1097-6256 |
| DOI: | 10.1038/s41593-018-0190-5 |
| Popis: | Protein kinases are key regulators of excitatory synapse plasticity. In this issue, using novel optical reporters of protein kinase C (PKC) activity, Colgan et al. identify PKCα as critical for integrating NMDA receptor and neurotrophin signaling to control dendritic spine structural plasticity, synaptic potentiation, and learning and memory. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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