Intestinal Absorption, Pharmacokinetics and Tissue Distribution of Gossypol Nanosuspensions

Autor:	Si Tao Yang, Hui Tang, Jian Chen Wang, Xue Ying, Bing Bing Wu
Rok vydání:	2014
Předmět:	chemistry.chemical_compound Materials science Pharmacokinetics chemistry Gossypol Polyphenol Plasma concentration General Engineering Mononuclear phagocyte system Tissue distribution Pharmacology Intestinal absorption
Zdroj:	Advanced Materials Research. 1015:708-712
ISSN:	1662-8985
DOI:	10.4028/www.scientific.net/amr.1015.708
Popis:	Gossypol (GP) is a kind of poorly water-soluble polyphenolic compounds. In this study, gossypol nanosuspensions (GP-NS) were prepared. The ability of intestinal absorption was evaluated. The result indicated that GP-NS could be absorbed in whole intestinal sections and permeated across the intestine, the process of gossypol nanosuspensions were not affected by P-gp efflux.The pharmacokinetics and tissue distribution of GP-NS after intravenous administration to mice was studied. GP-NS resulted in a higher plasma concentration and lower clearance.The tissue distribution study indicated that GP-NS showed a high uptake in reticuloendothelial system organs. In conclusion, the nanosuspensions system is a promising approach for gossypol.
Databáze:	OpenAIRE
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