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It is generally accepeted that there is no correlation between aspirin (ASA) dosage and antithrombotic effect. This hypothesis was tested by devising an animal model of thrombosis consisting of an A-V shunt with flow rate controlled at 200 ml/sec. The occlusion time (T-O) was found to be dependent upon formation of a platelet rich thrombus confirmed by electron microscopy. Three groups of dogs (4 in each group) were treated with 3 dosages of ASA (160, 325, and 650 mg BID for 4 days) and mean T-O under treatment was divided by mean T-O during a control period to obtain an index of prolongation of T-O by ASA in each animal. The mean indexes of prolongation for the groups were 1.31±0.14 (160 mg), 1.41±0.12 (325 mg), and 2.67±0.32 (650 mg), with the last being significantly greater (p |
