An efficient asymmetric synthesis of azetidine 2-phosphonic acids

Autor:	François Couty, Nicolas Rabasso, Claude Agami
Rok vydání:	2002
Předmět:	Organic Chemistry Azetidine Enantioselective synthesis Alcohol Alkylation Biochemistry Phosphonate chemistry.chemical_compound chemistry Aminophosphonate Drug Discovery polycyclic compounds Organic chemistry Moiety Stereoselectivity
Zdroj:	Tetrahedron Letters. 43:4633-4636
ISSN:	0040-4039
Popis:	Substituted azetidinic 2-phosphonates were prepared in diastereoisomerically and enantiomerically pure form, starting from readily available β-amino alcohols. This synthesis involved a three-step sequence: (i) N-alkylation of the starting amino alcohol with a methylene phosphonate moiety, (ii) chlorination of the alcohol, and (iii) stereoselective 4-exo-tet ring closure through an intramolecular alkylation of the lithiated aminophosphonate.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::02fcc4fec70ecc8598d2e3d4fb27cd35 https://doi.org/10.1016/s0040-4039(02)00868-7 Zobrazit plný text záznamu Full Text from ScienceDirect