Therapeutic Efficacy of Kumquat-Loaded Chitosan Nanoparticles against Toxoplasmosis in mice model
| Autor: | Zainab Abdul-Wahhab Salem, Nahed Samy, Wafaa Abd El-Hamed, Ahmed A. Abd-Rabou |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
biology
SOD3 business.industry Spiramycin Toxoplasma gondii Pharmacology biology.organism_classification medicine.disease Malondialdehyde medicine.disease_cause Toxoplasmosis chemistry.chemical_compound chemistry Catalase medicine biology.protein business Interleukin 6 Oxidative stress medicine.drug |
| Zdroj: | Egyptian Journal of Chemistry. |
| ISSN: | 2357-0245 |
| Popis: | The goal of this study was to compare the effects of kumquat extract and its chitosan nanoparticles on biochemical, histopathological, and parasitological factors in mice infected with Toxoplasma gondii versus spiramycin and control groups. A total of 35 mice, 7 of which were negative control and 28 was infected group, were used in the current study. All mice were sacrificed at 45 day after inoculation. Blood samples were collected. Then, sera Malondialdehyde (MDA), Catalase (CAT), Superoxide Dismutase 3 (SOD3), α-glutathione S-transferases (α-GST), and Interleukin 6 (IL-6) concentrations were measured using ELISA technique. In infected groups, CAT, SOD3, α-GST levels were decreased significantly (P |
| Databáze: | OpenAIRE |
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