Amphichoterpenoids A–C, unprecedented picoline-derived meroterpenoids from the ascidian-derived fungus Amphichorda felina SYSU-MS7908
| Autor: | Zhaoming Liu, Minghua Jiang, Zhenger Wu, Senhua Chen, Huimin Yin, Siwen Yuan, Qilin Wu, Heng Guo, Lan Liu |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Circular dichroism
biology Stereochemistry 02 engineering and technology General Chemistry Fungus 010402 general chemistry 021001 nanoscience & nanotechnology biology.organism_classification 01 natural sciences Acetylcholinesterase 0104 chemical sciences chemistry.chemical_compound chemistry Picoline 0210 nano-technology IC50 |
| Zdroj: | Chinese Chemical Letters. 32:1893-1896 |
| ISSN: | 1001-8417 |
| DOI: | 10.1016/j.cclet.2021.01.027 |
| Popis: | Amphichoterpenoids A–C (1–3), unprecedented picoline-derived meroterpenoids possessing a pyrano[3,2-c]pyridinyl-γ-pyranone scaffold, were characterized from the ascidian-derived fungus Amphichorda felina SYSU-MS7908. Their structures were elucidated by spectroscopic methods, X-ray diffraction and electronic circular dichroism (ECD) calculations. A plausible biosynthetic pathway was proposed. The isolated compounds displayed moderate inhibitory activity against acetylcholinesterase with 50% inhibiting concentration (IC50) values of 18.8–53.2 μmol/L. |
| Databáze: | OpenAIRE |
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