Effects of Renin-Angiotensin-Aldosterone System Blockade on Chlorhexidine Gluconate-Induced Sclerosing Encapsulated Peritonitis in Rats
| Autor: | Hesna Müzeyyen Astarcı, Gülay Koçak, Mevlut Ceri, Gökhan Karaca, Alper Azak, Bülent Huddam, Mehmet Sert, Murat Can, Murat Duranay |
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| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
business.industry medicine.medical_treatment Urology Peritonitis Hematology Aliskiren medicine.disease Peritoneal dialysis Neovascularization chemistry.chemical_compound Endocrinology chemistry Valsartan Nephrology Fibrosis Internal medicine Renin–angiotensin system medicine medicine.symptom business Peritoneal Fibrosis medicine.drug |
| Zdroj: | Therapeutic Apheresis and Dialysis. 16:75-80 |
| ISSN: | 1744-9979 |
| Popis: | Sclerosing encapsulated peritonitis (SEP) is a rare complication of long term peritoneal dialysis. Renin-angiotensin-aldosterone system (RAAS) may play a role in the development of peritoneal fibrosis in CAPD patients. We aimed to evaluate the effect of aliskiren, valsartan, and aliskiren + valsartan therapy on SEP. The study included 30 Wistar albino rats which were divided into five groups: I (Control) SF solution i.p.; II (CG group) chlorhexidine gluconate i.p.; III aliskiren oral plus CG i.p.; IV valsartan oral plus CG i.p.; and V aliskiren oral, valsartan oral and CG i.p. On the twenty-first day, all of the rats were sacrificed. All of the groups were analyzed in terms of peritoneal thickness, degree of inflammation, vasculopathy, neovascularization and fibrosis. Also, the parietal peritoneal tissue samples were evaluated for matrix metalloproteinase 2 (MMP-2) using the ELISA method. Peritoneal thickness and fibrosis scores were lower in the valsartan group compared to the CG group (P 0.05). Tissue MMP-2 levels were significantly higher in the CG group compared other groups (P |
| Databáze: | OpenAIRE |
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