Synthesis, characterization, and anticancer studies of S and N alkyl piperazine-substituted positional isomers of 1,2,4-triazole derivatives

Autor:	M. S. R. Murty, Rajesh Pamanji, Janapala Venkateswara Rao, Rayudu Venkateswara Rao, Kesur R. Ram, B. Ramalingeswara Rao, L. R. Velatooru, Mohana Rao Katiki
Rok vydání:	2013
Předmět:	chemistry.chemical_classification Chemistry Stereochemistry Organic Chemistry 1 2 4-Triazole Biological activity Structural property chemistry.chemical_compound Piperazine Structural isomer General Pharmacology Toxicology and Pharmaceutics Cytotoxicity Human cancer Alkyl
Zdroj:	Medicinal Chemistry Research. 23:1661-1671
ISSN:	1554-8120 1054-2523
DOI:	10.1007/s00044-013-0757-3
Popis:	A series of 3-[3-[4-(substituted)-1-cyclicamine]propyl]thio-5-substituted[1,2,4]triazoles (8a–m) and 2-[3-[4-(substituted)-1-cyclicamine]propyl]-5-(substituted)-2,4-dihydro-3H[1,2,4]triazole-3-thiones (9a–h) were synthesized with good yields starting from corresponding carboxylic acids using two different methods. The cytotoxicity studies of these derivatives were studied against five different human cancer cell lines. Six compounds had shown good anticancer activity. The triazole derivatives, 9d, 8j, and 8i were most potent particularly against U937 and HL-60 cells. The cytotoxic potency of the compounds varied between the cell lines suggesting that a structural property of these compounds as possible determinant of their biological activity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::02eae2c73d650728459d67f0f872adee https://doi.org/10.1007/s00044-013-0757-3 Zobrazit plný text záznamu Full text from SpringerLink