Aldehyde dehydrogenase 1 expression predicts poor prognosis in triple-negative breast cancer
| Autor: | Takako Yoshioka, Yasuyo Ohi, Yoshihisa Umekita, Yoshiaki Sagara, Yoshiaki Rai, Masakazu Souda, Yoshiatsu Sagara, Yasuaki Sagara, Akihide Tanimoto |
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| Rok vydání: | 2011 |
| Předmět: |
Oncology
medicine.medical_specialty Histology Stromal cell biology business.industry General Medicine medicine.disease Pathology and Forensic Medicine Cytokeratin Breast cancer Internal medicine Carcinoma biology.protein Immunohistochemistry Medicine Clinical significance Epidermal growth factor receptor skin and connective tissue diseases business Triple-negative breast cancer |
| Zdroj: | Histopathology. 59:776-780 |
| ISSN: | 0309-0167 |
| DOI: | 10.1111/j.1365-2559.2011.03884.x |
| Popis: | Ohi Y, Umekita Y, Yoshioka T, Souda M, Rai Y, Sagara Y, Sagara Y, Sagara Y & Tanimoto A (2011) Histopathology59, 776–780 Aldehyde dehydrogenase 1 expression predicts poor prognosis in triple-negative breast cancer Aims: Aldehyde dehydrogenase 1 (ALDH1) has been identified as a reliable marker of breast cancer stem cells, and its clinical significance as a prognostic indicator of breast cancer has been reported by several investigators. However, the clinical significance of ALDH1 expression in triple-negative (TN) breast cancer, a high-risk breast cancer lacking the benefit of specific therapy, remains to be solved. Methods and results: We performed immunohistochemical analyses of 106 TN breast cancers, using paraffin-embedded sections. The basal-like phenotype was also investigated with the use of basal cytokeratin 5/6 and epidermal growth factor receptor. ALDH1 expression in carcinoma cells was found in 59% of cases and was correlated with high histological grade alone (P |
| Databáze: | OpenAIRE |
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