P5984Clinical results and predictors of long-term mortality after Transcatheter Aortic Valve Replacement in according to gender

Autor:	Juan José Gómez-Doblas, M Munoz-Garcia, Fernando Carrasco-Chinchilla, Antonio J. Domínguez-Franco, A J Munoz Garcia, M F Jimenez-Navarro, Erika Muñoz-García, J M Hernandez-Garcia, J H Alonso-Briales
Rok vydání:	2019
Předmět:	medicine.medical_specialty Valve replacement Transcatheter aortic business.industry Internal medicine medicine.medical_treatment medicine Cardiology Long term mortality Cardiology and Cardiovascular Medicine business
Zdroj:	European Heart Journal. 40
ISSN:	1522-9645 0195-668X
DOI:	10.1093/eurheartj/ehz746.0705
Popis:	Although it is well known, the differences between both sexes in cardiovascular disease, however, there is a lack of data in aortic valve, treated with Transcatheter Aortic Valve Replacement (TAVR). The purpose of our study was to analyze the long-term clinical results of patients treated with TAVR in the female and male population. Material Between April 2008 and December 2017, 647 patients with aortic stenosis and 20 patients with aortic prosthesis dysfunction, were treated with TAVR consecutively in our center. The primary objective was to analyze, by Cox regression, the predictors of long-term mortality in both sexes. Results 59.1% were women. Males had a higher number of comorbidities and after a mean follow-up of 2.87±2.2 years (range between 0 and 9 years), mortality was higher for male patients 40.7% vs. 32% (HR = 1.447 [95% CI 1.057–2.009], p=0.022) and there were no differences for the presence of threatening bleeding (HR = 1.654 [IC95% 0.719–3.808], p=0.237), myocardial infarction (HR = 1,768 [IC95% 0.753–4.132], p=0.191), stroke (HR = 0.992 [IC95% 0.564–1.743], p=0.976) and hospitalizations for heart failure (HR = 1.388 [IC95% 0.811–2.376], p=0.231). Among the predictors of long-term mortality, common to both sexes were: threatening bleeding, heart failure, Charlson index, Karnofsky, and STS score. Conclusion In our series, there was clinical differences between both sexes, which has an impact on survival, being worse for men due to comorbidities, however, in the population of patients with aortic stenosis treated with TAVI, we found predictors of late mortality similarities between in female and male.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::02e681dbd6fbc1dd5186f9c3e4578003 https://doi.org/10.1093/eurheartj/ehz746.0705 Zobrazit plný text záznamu