Thermosensitive in situ liposomal gels loaded with antimicrobial agent for oral care in critically ill patients
| Autor: | S Salwa, S. N. Murthy, Marzieh Zare, K. Vanaja, Brinda Basavaraju, H.N. Shivakumar |
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| Rok vydání: | 2020 |
| Předmět: |
Liposome
business.industry Critically ill Pharmaceutical Science Pneumonia ventilator associated Antimicrobial Oral cavity medicine.disease 030226 pharmacology & pharmacy Meropenem 03 medical and health sciences Pneumonia 0302 clinical medicine 030220 oncology & carcinogenesis Anesthesia Medicine business Gamma irradiation medicine.drug |
| Zdroj: | Therapeutic Delivery. 11:231-243 |
| ISSN: | 2041-6008 2041-5990 |
| DOI: | 10.4155/tde-2019-0092 |
| Popis: | Aim: A novel thermosensitive in situ gel loaded with meropenem (MP) liposomes was designed to improve retention in the oral cavity as a prophylactic measure to prevent ventilator-acquired pneumonia in critically ill patients. Methodology & results: Meropenem liposomes were incorporated into poloxamer 407 gels and gamma irradiated. Mean size of liposome was 247 nm, polydispersity index < 0.3 and zeta potential >-25 mV; properties remained unaltered even post sterilization. Permeation study revealed that 75.26% and 34% of MPs were released from MP in situ gel and MP in situ liposomal gel, respectively. The relation between viscosity (cp) and shear rate (1/s) indicate that in situ gels exhibited non-Newtonian behavior at 37°C. The study using Pseudomonas aeruginosa confirmed the antimicrobial activity of meropenem. Conclusion: Prolonged in situ residence, because of rapid gelation process enables an easy administration of meropenem as liposomal suspension in critically ill patients. |
| Databáze: | OpenAIRE |
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