Relationship between alpha-1-acid glycoprotein concentration and plasma protein binding of mexiletine after acute myocardial infarction. Comparative study with disopyramide
| Autor: | Yasuaki Hashimoto, Yasuaki Kurozumi, Tsutomu Inoh, Satoshi Ishido, Tsutomu Kuroda, Takashi Yano, Takayoshi Azumi, Tetsuya Inatome, Kojiro Awano, Yasuhiro Yoshihara, Ryohei Kuroda |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Pharmacology
medicine.medical_specialty biology Chemistry Significant difference Orosomucoid Plasma protein binding medicine.disease Heart disorder Endocrinology Free fraction Internal medicine Mexiletine Anesthesia medicine biology.protein Pharmacology (medical) Myocardial infarction Disopyramide medicine.drug |
| Zdroj: | Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics. 21:771-776 |
| ISSN: | 1882-8272 0388-1601 |
| DOI: | 10.3999/jscpt.21.771 |
| Popis: | The influence of alpha-i-acid glycoprotein (AAG.) concentration on plasma protein binding of mexiletine and of disopyramide were investigated in patients with acute myocardial infarction and other heart disorders. The following results were obtained:(1) There was a linear relationship between the dose and plasma total concentration of mexiletine. There was no significant correlationship between the dose and plasma total concentration of disopyramide.(2) There was no significant correlationship between the concentration of AAG and free fraction of mexiletine, and negative correlation was observed between the concentration of AAG and free fraction of disopyramide.(3) No significant differences were observed in patients with acute myocardial infarction and other heart disorders between total plasma concentration and free fraction of mexiletine.There was no significant difference in total plasma concentration of disopyramide between the patients with acute myocardial infarction and other heart disorders. The free fraction in patients with acute myocardial infarction was significantly lower than that in those with other heart disorders (P |
| Databáze: | OpenAIRE |
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