New cytotoxic steroidal saponins from Cestrum parqui
| Autor: | Amir E. Wahba, Mohamed H. Ali, Hala M. Shaaban, Radwa R. Mosad, Marwan Emara, Magda T. Ibrahim |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
chemistry.chemical_classification
biology 010405 organic chemistry Stereochemistry Cestrum parqui Glycoside Plant Science biology.organism_classification 01 natural sciences Biochemistry 0104 chemical sciences HeLa 010404 medicinal & biomolecular chemistry chemistry Cytotoxic T cell Agronomy and Crop Science Two-dimensional nuclear magnetic resonance spectroscopy Biotechnology |
| Zdroj: | Phytochemistry Letters. 22:167-173 |
| ISSN: | 1874-3900 |
| DOI: | 10.1016/j.phytol.2017.09.022 |
| Popis: | Two new steroidal saponins, 25(R)-3β [( O -β- d -glucopyranosyl-(1 → 3)-β- d -glucopyranosyl-(1 → 2)- O -[β- d -xylopyranosyl-(1 → 3)- O -β- d -glucopyranosyl-(1 → 4)-β- d -galactopyranosyl)oxy]-5α, 15β, 22 R , 25 R -spirostan-3,15-diol ( 1, named parquispiroside ) and 25 R -26-[(β- d -glucopyranosyl)Oxy]-(3β [( O -β- d -glucopyranosyl-(1 → 3)-β- d -glucopyranosyl-(1 → 2)- O -[β- d -xylopyranosyl-(1 → 3)- O -β- d -glucopyranosyl-(1 → 4)-β- d -galactopyranosyl)oxy], 5α, 15β, 22 R , 25 R )-furostane-3,15,22-triol ( 2, named parquifuroside ), along with the known saponins, capsicoside D ( 3 ) and 22-OMe-capsicoside D ( 4 ) and the known glycoside, benzyl primeveroside ( 5 ), were isolated from the leaves of Cestrum parqui . The structures of these compounds were elucidated by careful analysis of 1D and 2D NMR spectra and ESIMS data. Parquispiroside ( 1 ) exhibited moderate inhibition of Hela, HepG2, U87, and MCF7 cell lines with IC 50 values in the range of 3.3–14.1 μM. |
| Databáze: | OpenAIRE |
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