Efficacy of topical cinnamon gel for the treatment of facial acne vulgaris: A preliminary study
| Autor: | Saman Ahmad Nasrollahi, Gholamreza Kord Afshari, Mahdi Vazirian, Alireza Firooz, Sima Kolahdooz, Maedeh Ghovvati, Aniseh Samadi, Mehrdad Karimi, Ziba Talebi |
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| Rok vydání: | 2019 |
| Předmět: |
Biophysical profile
medicine.medical_specialty Erythema business.industry medicine.disease 01 natural sciences Dermatology General Biochemistry Genetics and Molecular Biology Chronic disorders 0104 chemical sciences Clinical trial 010404 medicinal & biomolecular chemistry 03 medical and health sciences 0302 clinical medicine 030220 oncology & carcinogenesis Medicine Medicinal herbs In patient medicine.symptom business Acne Adverse drug reaction |
| Zdroj: | Biomedical Research and Therapy. 6:2958-2965 |
| ISSN: | 2198-4093 |
| DOI: | 10.15419/bmrat.v6i1.515 |
| Popis: | Background: Acne vulgaris is a common chronic disorder of the pilosebaceous unit. Topical therapy is the mainstay of treatment for mild-to-moderate acne. Two main problems with conventional anti-acne treatments are antibiotic resistance and local side effects. In this regard, medicinal herbs could be an alternative choice for developing new products with fewer side effects. Objective: The purpose of this study was to evaluate the safety and efficacy of a topical formulation of cinnamon in patients with facial acne. Method: In this open-label, assessor-blind, and uncontrolled clinical trial, 20 patients (18F/2M) with mild-to-moderate facial acne were treated with topical cinnamon gel twice-daily for eight weeks. The outcomes of acne lesion count, red fluorescence parameters and skin biophysical profile were evaluated at baseline, 4th and 8th week. For safety assessment, any adverse drug reaction was recorded during the study. Results: Two months after using cinnamon gel, there was a significant reduction in the total (47%, p=0.000), inflammatory (42%, p=0.026), and non-inflammatory (48%, p=0.002) lesion count. Also, the size of red fluorescence spots was significantly reduced (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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