The effect of endurance training and subsequent physical inactivity on glycaemic control after oral glucose load and physical exercise in healthy men

Autor:	H. Kaciuba-Uscilko, Zofia Radikova, Lucia Kšinantová, Juraj Koska, Milan Vigas, Krystyna Nazar
Rok vydání:	2007
Předmět:	medicine.medical_specialty business.industry medicine.medical_treatment Insulin Aerospace Engineering Insulin sensitivity Physical exercise Carbohydrate metabolism Bed rest Endocrinology Endurance training Statistical significance Internal medicine medicine Oral glucose business
Zdroj:	Acta Astronautica. 60:301-306
ISSN:	0094-5765
Popis:	Physical inactivity during space flight has a profound effect on glucose metabolism. The aim of this study was to test whether endurance training (ET) may improve a negative effect of subsequent - 6 ∘ head-down bed rest (HDBR) on glucose metabolism. Fourteen healthy males completed the study consisting of 6 weeks lasting ET followed by 6 days HDBR. Treadmill exercise at 80% of pre-training VO 2 max and 75 g oral glucose tolerance test (OGTT) were performed before and after ET as well as after HDBR. ET increased VO 2 max by 11%. ET significantly lowered while HDBR had no effect on fasting and OGTT plasma glucose levels. ET had no effect while HDBR was followed by an augmentation of insulin and C-peptide response to OGTT. Insulin sensitivity tended to increase after ET and to decrease during HDBR, however, mostly without statistical significance. Plasma glucose, insulin and C-peptide response to exercise were elevated after HDBR only. Our study shows that antecedent physical training could ameliorate a negative effect of simulated microgravity on insulin-mediated glucose metabolism.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::02d1481047f083486205562aff8e9e5d https://doi.org/10.1016/j.actaastro.2006.08.011 Zobrazit plný text záznamu Full Text from ScienceDirect