Lessons learned from a comparison of evidence-based research in pregnant opioid-dependent women
| Autor: | Kenneth Thau, Martin Langer, Bernadette Winklbaur-Hausknost, K. Graf-Rohrmeister, Gabriele Fischer, Reinhold Jagsch, Andjela Baewert, Annemarie Unger |
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| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
Pregnancy business.industry Contingency management medicine.disease law.invention Clinical trial Psychiatry and Mental health Neurology Randomized controlled trial Opioid law Internal medicine Anesthesia medicine Pharmacology (medical) Neurology (clinical) Young adult business Buprenorphine medicine.drug Methadone |
| Zdroj: | Human Psychopharmacology: Clinical and Experimental. 28:15-24 |
| ISSN: | 0885-6222 |
| DOI: | 10.1002/hup.2275 |
| Popis: | Objectives Lessons learned in research and treatment of opioid dependence demonstrate the need to include pregnant women in clinical trials. Methods Two double-blind, double-dummy, randomized controlled trials (Pilot study, European sample† of MOTHER-trial) comparing buprenorphine and methadone in opioid-dependent pregnant women were conducted. In both studies, participants received voucher-based incentives for attendance and completion of study assessments. In the MOTHER trial, participants additionally received escalating voucher incentives for drug-free urine samples. Neonatal abstinence syndrome was treated with oral morphine solution based on standardized modified Finnegan scores. Results After a mean treatment period of 13.79 weeks in the Pilot study (PS, n = 18) and 20.78 weeks in the MOTHER-trial (MT, n = 41), respectively (p |
| Databáze: | OpenAIRE |
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