Severe dietary restriction initiated in aged rats: evidence for poor adaptation in terms of protein metabolism and intestinal functions
| Autor: | C. Felgines, Francis Raul, J.-P. Cezard, Marie-Paule Vasson, P. Pernet, Luc Cynober, M. C. Farges, C. Chambon-Savanovitch |
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| Rok vydání: | 1999 |
| Předmět: |
medicine.medical_specialty
Malabsorption Protein–energy malnutrition Clinical Biochemistry Protein metabolism General Medicine Biology medicine.disease Biochemistry chemistry.chemical_compound Malnutrition Atrophy Endocrinology Intestinal mucosa chemistry Tibialis anterior muscle Internal medicine medicine Splanchnic |
| Zdroj: | European Journal of Clinical Investigation. 29:504-511 |
| ISSN: | 0014-2972 |
| DOI: | 10.1046/j.1365-2362.1999.00469.x |
| Popis: | Background Protein energy malnutrition is a common finding in elderly people, increasing morbidity and mortality in aged inpatients. Investigations need to be developed to counteract malnutrition-induced alterations early and to avoid potential irreversible lesions. The aim of this experimental study was to evaluate time-response to severe dietary restriction (DR) initiated in aged rats in terms of protein metabolism and digestive trophicity. Materials and methods After the acclimatization period, 22-month-old male rats were randomized into six groups: three control groups, fed ad libitum for 3, 6 or 12 weeks with a standard diet and three corresponding dietary-restricted groups fed for the same periods with only 50% of the spontaneous intake. Intestinal mucosa, liver and skeletal muscles (soleus, extensor digitorum longus and tibialis anterior muscle) were removed when the rats were killed. Results DR induced dramatic body weight loss (up to 50% of initial body weight after 12 weeks DR). Protein metabolism was affected in terms of nitrogen balance (P |
| Databáze: | OpenAIRE |
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