Qingre Quyu Granule (清热祛瘀颗粒) stabilizes plaques through inhibiting the expression of tenascin-C in patients with severe carotid stenosis
Autor: | Lin Pan, Jie Yuan, Jian Guo, Li Chen, Jing-pin Peng, Yi Wang, Wen-li Cheng, Hong Li, Yong Wang |
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Rok vydání: | 2015 |
Předmět: |
medicine.medical_specialty
Pathology CD40 biology CD68 business.industry medicine.medical_treatment Therapeutic effect Tenascin C General Medicine MMP9 medicine.disease Gastroenterology Stenosis Complementary and alternative medicine Internal medicine medicine biology.protein Immunohistochemistry Pharmacology (medical) business Endarterectomy |
Zdroj: | Chinese Journal of Integrative Medicine. 21:339-345 |
ISSN: | 1993-0402 1672-0415 |
Popis: | To investigate the therapeutic effects of Qingre Quyu Granule (清热祛瘀颗粒, QQG) on the patients with severe carotid stenosis, and to explore the mechanism of it. Ninety-six patients with severe carotid stenosis were enrolled in the study and were classified into a QQG group (n=48) and a control group (n=48) randomly using consecutively numbered envelopes. The patients in the QQG group were given QQG and Western medicine, those in the control group were given Western medicine merely, the course of treatment was 16 weeks. All patients went through endarterectomy after treatment. Plaques were subjected to the analysis of CD3, CD68, soluble intercellular adhesion molecule 1 (ICAM-1), matrix metalloprotease-9 (MMP-9), CD40L, tenascin-C, and collagen content lipid content by immunohistochemistry or polarized light analysis. By the end of experiment, the expressions of CD3, CD68, ICAM-1, MMP9, CD40L and tenascin-C on the plaques were statistically significant lower in the QQG group compared with the control group(P |
Databáze: | OpenAIRE |
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