Qingre Quyu Granule (清热祛瘀颗粒) stabilizes plaques through inhibiting the expression of tenascin-C in patients with severe carotid stenosis

Autor: Lin Pan, Jie Yuan, Jian Guo, Li Chen, Jing-pin Peng, Yi Wang, Wen-li Cheng, Hong Li, Yong Wang
Rok vydání: 2015
Předmět:
Zdroj: Chinese Journal of Integrative Medicine. 21:339-345
ISSN: 1993-0402
1672-0415
Popis: To investigate the therapeutic effects of Qingre Quyu Granule (清热祛瘀颗粒, QQG) on the patients with severe carotid stenosis, and to explore the mechanism of it. Ninety-six patients with severe carotid stenosis were enrolled in the study and were classified into a QQG group (n=48) and a control group (n=48) randomly using consecutively numbered envelopes. The patients in the QQG group were given QQG and Western medicine, those in the control group were given Western medicine merely, the course of treatment was 16 weeks. All patients went through endarterectomy after treatment. Plaques were subjected to the analysis of CD3, CD68, soluble intercellular adhesion molecule 1 (ICAM-1), matrix metalloprotease-9 (MMP-9), CD40L, tenascin-C, and collagen content lipid content by immunohistochemistry or polarized light analysis. By the end of experiment, the expressions of CD3, CD68, ICAM-1, MMP9, CD40L and tenascin-C on the plaques were statistically significant lower in the QQG group compared with the control group(P
Databáze: OpenAIRE