MO452CHRONIC KIDNEY DISEASE TEN YEARS AFTER PEDIATRIC ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION

Autor:	Carlijn C.E. Jordans, Dorine Bresters, Arjan C. Lankester, Roos W.G. van Rooij-Kouwenhoven, Els C. Jol-van der Zijde, Gertjan Lugthart, Anne P.J. de Pagter, Eiske M. Dorresteijn, Rám N. Sukhai, Marloes Louwerens
Rok vydání:	2021
Předmět:	Transplantation Pathology medicine.medical_specialty surgical procedures operative Nephrology business.industry medicine.medical_treatment medicine Hematopoietic stem cell transplantation medicine.disease business Kidney disease
Zdroj:	Nephrology Dialysis Transplantation. 36
ISSN:	1460-2385 0931-0509
DOI:	10.1093/ndt/gfab090.0014
Popis:	Background and Aims Chronic kidney disease (CKD) is an important sequela of hematopoietic stem cell transplantation (HSCT), but data regarding CKD after pediatric HSCT are limited. Method In this single center cohort study, we evaluated eGFR dynamics, proteinuria and hypertension in the first decade after HSCT and assessed risk factors for chronic kidney disease in 216 pediatric long term HSCT survivors, transplanted between 2002 and 2012. Results The eGFR decreased from median 148 to 116 ml/min/1.73m2 between pre-HSCT and ten years after HSCT. CKD, defined as an eGFR Conclusion In conclusion, a significant proportion of pediatric HSCT recipients developed chronic kidney disease within ten years after HSCT. Our data stress the importance of structural long term monitoring of eGFR, urine and blood pressure after HSCT to identify patients with beginning CKD who could benefit most from nephroprotective interventions.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::02c38061ebd179dade78a58405ba612a https://doi.org/10.1093/ndt/gfab090.0014 Zobrazit plný text záznamu