Ratiometric fluorescence for sensitive and selective detection of mitoxantrone using a MIP@rQDs@SiO2 fluorescence probe
| Autor: | Wei Zhang, Jiong-Xiu Pan, Jing Zhang, Chen Huayan, Jing-Ru Wei, Fuquan Dang, Zhi-Qi Zhang |
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| Rok vydání: | 2017 |
| Předmět: |
Analytical chemistry
02 engineering and technology 01 natural sciences chemistry.chemical_compound Materials Chemistry medicine Electrical and Electronic Engineering Instrumentation Detection limit Mitoxantrone Chromatography 010401 analytical chemistry Metals and Alloys Molecularly imprinted polymer 021001 nanoscience & nanotechnology Condensed Matter Physics Fluorescence Ratiometric fluorescence 0104 chemical sciences Surfaces Coatings and Films Electronic Optical and Magnetic Materials Monomer chemistry Linear range Quantum dot 0210 nano-technology medicine.drug |
| Zdroj: | Sensors and Actuators B: Chemical. 244:31-37 |
| ISSN: | 0925-4005 |
| DOI: | 10.1016/j.snb.2016.12.091 |
| Popis: | Molecularly imprinted polymer coated quantum dots (MIP@rQDs@SiO 2 ) fluorescence probe combined with ratiometric fluorescence technique has been applied to the selective and sensitive detection of mitoxantrone (MIT) for the first time. The MIP@rQDs@SiO 2 fluorescence probe was synthesized with the mole ratio of template, monomer and cross-linker at 1:4:12. The proposed method can quickly detect mitoxantrone in human serum and urine samples at pH 6.5 within 10 min. The linear range for MIT concentrations was 0.2 μM–2.0 μM, and the detection limit was as low as 0.067 μM. The MIP@rQDs@SiO 2 ratiometric fluorescence probe, which integrated the high selectivity of MIP and high sensitivity of the ratiometric fluorescence probe, possesses greater sensitivity and reliability than a single quantum dot MIP fluorescence probe. |
| Databáze: | OpenAIRE |
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