A new method for the conversion of secondary and tertiary amides to bridged orthoesters

Autor:	André B. Charette, Peter C. Chua
Rok vydání:	1997
Předmět:	chemistry.chemical_compound chemistry Organic Chemistry Drug Discovery Pyridine Iminium Biochemistry Medicinal chemistry Octane
Zdroj:	Tetrahedron Letters. 38:8499-8502
ISSN:	0040-4039
DOI:	10.1016/s0040-4039(97)10310-0
Popis:	Secondary and tertiary amides were treated with trifluoromethanesulfonic (triflic) anhydride in the presence of pyridine at low temperatures to generate imino and iminium triflates. Successive treatment with 2,2-bishydroxymethyl-1-propanol in the pyridine buffered solution gave the corresponding 2,6,7-trioxabicyclo[2.2.2]octane orthoesters in good to excellent yields at below room temperature.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::02b23c94c8d9e34084b63fa53beb40dc https://doi.org/10.1016/s0040-4039(97)10310-0 Zobrazit plný text záznamu Full Text from ScienceDirect