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The present report concerns a gas chromatographic-mass spectrometric study on the urinary excretion of steroids during a virilizing malignant corticoadrenaloma resulting in the identification of thirty five steroids. They are: twelve 17-oxo-steroids, two 5α-androstane-3α,17-diols, two 5-androsten-3β,17-diols, four 5-androstane-3α,16,17-triols, the 5β-androstane-3α,11β,17α-triol, the 5α-androstane-α,3α,17α-triol, the 5-androsten-3β,16α,17β-triol, the 3α,16α-dihydroxy-5α-pregnan-20-one, the 3β,17α-dihydroxy5α-pregnan-20-one, the 5β-pregnane-3α,20α-diol, the 5-pregnene-3β,20α-diol, the 5-pregnene-3α,16α,20αtriol, the 5β-pregnane-3α,17,20α-triol, the 5-pregnene-3β,17,20α-triol and the 3α, 17,21 -trihydroxy-5β -pregnan-20-one. The quantitative assay of these metabolites done by g.l.c., showed that the 17-oxo-steroid excretion, averaging 111,9 mg/24 h, was linked to a major excretion of 3/α-hydroxy-5-androsten-17-one, 3α-hydroxy-5β,androstan-17-one, 3α,11β-dihydroxy-5α-androstan-17-one, 3α-hydroxy-5α,androstan-17-one and 3β,16α-dihydroxy-5-androsten-17-one averaging respectively 46.80, 30, 17.40, 6.10 et 5.25 mg/24 h. The relatively important metabolites are 5β-pregnane-3α,17,20α-triol, 5-androsten-3β,17β,diol, 5α-androstane-3/gb,16β,17α-triol, 5β-androstane-3α,16α,17β-triol, 5α-androstane-3α,17β-diol and 3α,17,21-trihydroxy-5β-pregnan-20-one averaging respectively 9.80, 7.60, 6.95, 3.25, 2.90 and 2.35 mg/24 h. The identification of three 5-androstane-3,16β,17α-triols confirms the results of other authors which showed their formation from the 4,16-androstadien-3-one. |
