| Autor: |
K. Waalen, J. B. Natvig, Ø. Førre |
| Rok vydání: |
1992 |
| Předmět: |
|
| Zdroj: |
Rheumatoid Arthritis ISBN: 9783642761911 |
| DOI: |
10.1007/978-3-642-76189-8_6 |
| Popis: |
Endothelial cells (EC) and dendritic cells (DC) play an important role in rheumatoid inflammation. All types of inflammatory cells seem to emigrate to the synovial tissue by first binding to the high endothelial venules. Certain cytokines increase this binding and direct the cell traffic to the inflammatory sites. Interferon-γ stimulates EC to express HLA class-II molecules and to become accessory cells for T-cell activation. The dendritic cells are probably the most important accessory cells for the T-cell responses in the inflamed joint tissues. This is accomplished by their strong HLA class-II antigen expression, their large surface area, and their production of cytokines. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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