Biochemical and histological evaluation of benzo[a]pyrene induced nephrotoxicity and therapeutic potentials of Combretum zenkeri leaf extract
| Autor: | C. S. Alisi, C U Ogbonna, A. A. Emejulu, G N Okwu, C. O. Ujowundu, K. O. Igwe |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Pharmacology Kidney Creatinine Sodium Pharmaceutical Science chemistry.chemical_element Renal function Nephrotoxicity 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure chemistry Benzo(a)pyrene 030220 oncology & carcinogenesis medicine Urea Organic chemistry Pyrene |
| Zdroj: | African Journal of Pharmacy and Pharmacology. 10:873-882 |
| ISSN: | 1996-0816 |
| Popis: | This study determined the therapeutic effect of ethanol leaf extract of Combretum zenkeri on kidney function of rats exposed to benzo[a]pyrene. Male Wistar albino rats were treated with ethanol leaf extract of C. zenkeri (400 mg/kg) in the presence or absence of BaP (200 mg/kg) for four weeks. The blood obtained at the end of the treatment was processed into serum and used for biochemical analyses and kidney tissues for histology. The serum creatinine, urea, sodium ion and potassium ion concentrations of the group exposed to benzo[a]pyrene without treatment with C. zenkeri extracts were significantly higher (p |
| Databáze: | OpenAIRE |
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