Extended Studies on the Effect of Glutamate Antagonists on Ischemic CA-1 Damage

Autor:	I Vanicky, Thomas Christensen, Torben Balchen, Torben Bruhn, F. F. Johansen, Marianne Nielsen, Nils Henrik Diemer
Rok vydání:	1996
Předmět:	medicine.medical_specialty business.industry Antagonist Glutamate receptor Ischemia Brain damage AMPA receptor medicine.disease chemistry.chemical_compound Dose–response relationship Endocrinology chemistry Internal medicine Medicine NBQX medicine.symptom business Receptor
Zdroj:	Mechanisms of Secondary Brain Damage in Cerebral Ischemia and Trauma ISBN: 9783709194676
DOI:	10.1007/978-3-7091-9465-2_13
Popis:	Glutamate receptors are numerous on the ischemia vulnerable CA-1 pyramidal cells. Postischemic use of the AMPA antagonist NBQX has shown up to 80% protection against cell death. Three aspects of this were studied: In the first study, male Wistar rats were given NBQX (30 mg/kg × 3) either 20 hours or immediately (0 h) before 12 min of 4-vessel occlusion with hypotension. After six days of reperfusion comparison with an untreated group showed almost full protection in the 0 h group (4% cell loss, p < 0.001) but only slight protection in the 20 h group (62% cell loss, p < 0.05).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::0285f10f3ad76c1277cc8c3ed8f5873b https://doi.org/10.1007/978-3-7091-9465-2_13 Zobrazit plný text záznamu