Neurologic late effects associated with radiologic evidence of vertebral osteoradionecrosis after salvage laryngectomy: A syndrome associated with survivors of laryngeal and hypopharyngeal cancer
| Autor: | Avraham Eisbruch, Francis P. Worden, Jae Y. Lee, Garrett R. Griffin, Carol R. Bradford, Douglas B. Chepeha, Jeffrey M. Vainshtein, Jeffrey S. Moyer, Andrew J. Rosko, Mark E. Prince, Matthew E. Spector |
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| Rok vydání: | 2016 |
| Předmět: |
Neck pain
medicine.medical_specialty business.industry Osteoradionecrosis medicine.medical_treatment Pharynx Salvage therapy Hypopharyngeal cancer medicine.disease Surgery Laryngectomy 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Otorhinolaryngology 030220 oncology & carcinogenesis Back pain Medicine medicine.symptom business 030217 neurology & neurosurgery Chemoradiotherapy |
| Zdroj: | Head & Neck. 38:1187-1193 |
| ISSN: | 1043-3074 |
| DOI: | 10.1002/hed.24348 |
| Popis: | Background Delayed nonspecific posterior neck pain after pharyngeal instrumentation can be associated with a syndrome of rapidly progressive neurologic embarrassment. We present this cohort to help define the syndrome and aid in early detection. Methods We conducted a retrospective case series of 6 patients presenting from 2003 to 2012 with a history of laryngeal or hypopharyngeal squamous cell carcinoma (SCC) who underwent radiotherapy (RT) or chemoradiotherapy (CRT) followed by salvage laryngectomy. Results Posterior neck and upper back pain developed a mean of 27.5 days after instrumentation of the pharynx (reconstruction after laryngectomy or pharyngeal dilation). Myelopathy developed an average of 21.5 days after the onset of posterior neck pain. Five patients required urgent decompression. Three patients developed quadriplegia. The disease-specific mortality was 50%. Conclusion There is a syndrome of late neurological effects after RT, salvage surgery, and pharyngeal instrumentation that is associated with high morbidity and mortality. © 2015 Wiley Periodicals, Inc. Head Neck, 2015 |
| Databáze: | OpenAIRE |
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