In vivo vocal fold augmentation using an injectable polyethylene glycol hydrogel based on click chemistry
| Autor: | Choung-Soo Kim, Sangkee Choi, Heebeom Koo, Hyunsu Choi, Soonmin Kwon, Eunha Kim, Changhee Park, Sung Won Kim |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Chemistry
technology industry and agriculture Biomedical Engineering macromolecular substances Polyethylene glycol Polyethylene Glycol Hydrogel Subcutaneous injection chemistry.chemical_compound medicine.anatomical_structure In vivo Vocal folds PEG ratio otorhinolaryngologic diseases medicine Click chemistry General Materials Science Azide Biomedical engineering |
| Zdroj: | Biomaterials Science. 9:108-115 |
| ISSN: | 2047-4849 2047-4830 |
| DOI: | 10.1039/d0bm01155j |
| Popis: | It is important to focus on urgent needs in clinics and develop optimal materials. For successful augmentation of vocal folds, the ideal filler should be injectable through a syringe, and should stably maintain its volume for a long time without toxicity. To achieve these criteria, a click chemistry-based PEG (polyethylene glycol) hydrogel was developed and applied for vocal fold augmentation in vivo. The PEG hydrogel enables fast gelation in vivo after injection and provides long-term stability. Azide- and dibenzocyclooctyne (DBCO)-modified 4-arm PEG were cross-linked by chemical conjugation via click chemistry and yielded gelation within several minutes. After subcutaneous injection into mice and rats, the PEG hydrogel showed higher stability after 1 month compared to the traditionally used calcium hydroxyapatite–carboxymethyl cellulose (CaHA-CMC) filler. In rabbit models with vocal fold paralysis, the PEG hydrogel stably fixed the paralyzed vocal fold in 4 months and minimized the glottic gap. It was an improved therapeutic result compared to CaHA-CMC, demonstrating the potential of a click chemistry-based PEG hydrogel for vocal fold therapy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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