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Background: T follicular helper cell is considered to be involved in B cell and a subset of effector T cell maturing. Nodal peripheral T-cell lymphoma with T-follicular helper phenotype (NPTCL-TFH) is a subset of peripheral T-cell lymphoma defined by expression of at least 2 or 3 TFH markers. Here we report a case of typical NPTCL-TFH while the B cell marker CD20 is positive.Case presentation: A 62-year-old male presented to our hospital with a symptom of dizzy and neck mass for 10 days. Physical examination and PET/CT revealed right cervical, armpit and inguinal lymphadenopathy, some of which were accompanied by pain. In the nodule biopsy, lymph node structure is destroyed, completely effaced by intermediate-sized monotonous lymphoid cells with round nuclei and abundant mitosis. Immunohistochemical staining confirmed that tumor cells were positive for T cell marker, and expressed several markers of TFH (CD4, Bcl-6, CXCL-13 and PD-1 ). Besides, in situ hybridization of EB virus showed scattered positive and TCR gamma arrangement is positive. However, with all these evidences of NPTCL-TFH, the tissue weirdly expressed CD20, a B lymphocyte maturing marker. The patient gave up treatment and unfortunately was died of tumor cachexia after 4-5 months. Conclusions: We report the first case of CD20 positive in a NPTCL-TFH. More investigation and knowledge of this new phenotype need to be explored. |
