Shanpanootols G and H, Diterpenoids from the Rhizomes of Kaempferia pulchra Collected in Myanmar and Their Vpr Inhibitory Activities

Autor:	Hiroyuki Morita, Zin Paing Htoo, Nwet Nwet Win, Ikuro Abe, Saw Yu Yu Hnin, Takeshi Kodama, Hla Ngwe
Rok vydání:	2021
Předmět:	Circular dichroism Chemistry Stereochemistry Drug Discovery High resolution Viral Protein R General Chemistry General Medicine Kaempferia pulchra Mass spectrometric Rhizome
Zdroj:	Chemical and Pharmaceutical Bulletin. 69:913-917
ISSN:	1347-5223 0009-2363
Popis:	Two new trihydroxy derivative of Δ8(14),15-isopimarane diterpenoids, shanpanootols G (1) and H (2), along with three known analogues were isolated from the ethyl acetate-soluble extract of Kaempferia pulchra rhizomes collected in Shan State of Myanmar. The structures of these compounds including their absolute configurations were elucidated by the combination of one dimensional (1D) and 2D-NMR spectroscopic methods, high resolution mass spectrometric technique, and the experimental and the calculated electronic circular dichroism (ECD) data. The isopimarane diterpenoids (1-5) were tested for their Viral protein R (Vpr) inhibitory activities against TREx-HeLa-Vpr cells. Shanpanootol H (2) and (1R,2S,5S,9R,10S,13R)-1,2-dihydroxypimara-8(14),15-dien-7-one (4) exhibited anti-Vpr activities at the 5 µM treated dose.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::0265a7b507f9c4dc6b3fbedb725cc551 https://doi.org/10.1248/cpb.c21-00326 Zobrazit plný text záznamu