Association Studies of Polymorphisms of CYP2E1 Gene in Alcoholics with Cirrhosis, Antisocial Personality, and Normal Controls

Autor: C. R. Cloninger, A. Parsian, Z. H. Zhang
Rok vydání: 1998
Předmět:
Zdroj: Alcoholism: Clinical and Experimental Research. 22:888-891
ISSN: 1530-0277
0145-6008
Popis: To determine the role of CVP2€1 gene in susceptibility to alcoholism and alcohol cirrhosis, we gentoyped a sample of alcoholics with and without cirrhosis, alcoholics with antisocial personality, alcoholic families, and normal controls with Rsal, Pstl, and Dral polymorphisms in the gene. Relative risk and haplotype relative risk approaches were used in genotype data analysis. The Pstl polymorphism data were excluded from further analysis due to strong linkage disequilibrium with Rsal. For the Rsal polymorphism, comparison of total alcoholics, alcoholics with and without cirrhosis, and alcoholics with antisocial personality with normal controls were negative. The results of the same analysis with the above groups for Dral were also negative. Using the haplotype relative risk method, the result for Dral was positive, meaning that the mutated allele (D2) was significantly more transmitted than nontransmitted. However, the result of the same analysis for the Rsal polymorphism was not statistically significant. We conclude that the CYP2€1 gene plays no
Databáze: OpenAIRE
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