An Alternate Synthesis of Bosentan Monohydrate, an Endothelin Receptor Antagonist

Autor:	Ghojala Venkat Reddy, Porala Subbanarsimulu, Yerrabelly Jayaprakash Rao, Rebelli Pradeep, Yalamanchili Kumari Bharathi, Bairy Kondal Reddy
Rok vydání:	2013
Předmět:	chemistry.chemical_classification chemistry.chemical_compound Chemistry Endothelin receptor antagonist Bosentan monohydrate Dimer Reagent Organic Chemistry Methanol Combinatorial chemistry Sulfonamide
Zdroj:	Synlett. 25:265-269
ISSN:	1437-2096 0936-5214
Popis:	An alternate synthesis of an endothelin receptor antagonist bosentan monohydrate is reported. This new synthetic route involves the coupling of p - tert -butyl- N -[6-chloro-5-(2-methoxy-phenoxy)(2,2′-bipyrimidin)-4-yl]benzene sulfonamide with commercially available raw material (2,2-dimethyl-1,3-dioxolan-4-yl)methanol as the key step. Attractive features of this approach are its versatileness, commercial availability of raw materials, usage of eco-friendly reagents, and it efficiently provides the desired bosentan monohydrate free from reported impurities such as dimer, N-alkylated, and pyrimidinone impurities.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::0259db31ed395754862c08b7898b13fa https://doi.org/10.1055/s-0033-1340281 Zobrazit plný text záznamu