Mild cognitive impairment in Parkinson's disease is improved by transcranial direct current stimulation combined with physical therapy
| Autor: | Italo Orizio, Sandra Rosini, Alessandro Padovani, Michela Petesi, Chiara Cobelli, Michela Brambilla, Alberto Benussi, Clarissa Ferrari, Barbara Borroni, Rosa Manenti, Maria Cotelli |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Parkinson's disease Transcranial direct-current stimulation medicine.medical_treatment Neuropsychology Physical exercise Cognition medicine.disease Dorsolateral prefrontal cortex 03 medical and health sciences 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure Neurology medicine Physical therapy Verbal fluency test Neurology (clinical) Deep transcranial magnetic stimulation Psychology 030217 neurology & neurosurgery |
| Zdroj: | Movement Disorders. 31:715-724 |
| ISSN: | 0885-3185 |
| Popis: | Background Parkinson's disease (PD) is characterized by both motor and cognitive deficits. In PD, physical exercise has been found to improve physical functioning. Recent studies demonstrated that repeated sessions of transcranial direct current stimulation led to an increased performance in cognitive and motor tasks in patients with PD. Objectives The present study investigated the effects of anodal transcranial direct current stimulation applied over the dorsolateral prefrontal cortex and combined with physical therapy in PD patients. Methods A total of 20 patients with PD were assigned to 1 of 2 study groups: group 1, anodal transcranial direct current stimulation plus physical therapy (n = 10) or group 2, placebo transcranial direct current stimulation plus physical therapy (n = 10). The 2 weeks of treatment consisted of daily direct current stimulation application for 25 minutes during physical therapy. Long-term effects of treatment were evaluated on clinical, neuropsychological, and motor task performance at 3-month follow-up. Results An improvement in motor abilities and a reduction of depressive symptoms were observed in both groups after the end of treatment and at 3-month follow-up. The Parkinson's Disease Cognitive Rating Scale and verbal fluency test performances increased only in the anodal direct current stimulation group with a stable effect at follow-up. Conclusions The application of anodal transcranial direct current stimulation may be a relevant tool to improve cognitive abilities in PD and might be a novel therapeutic strategy for PD patients with mild cognitive impairment. © 2016 International Parkinson and Movement Disorder Society |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text