ChemInform Abstract: Synthesis and Biological Activity of O-Alkyl-3-N-aminoacyloxymethyl-5- fluoro-2′deoxyuridine Derivatives

Autor:	Naoyuki Harada, Kenji Tsujihara, Motoaki Ohohashi, Tomiki Hashiyama, Takayuki Kawaguchi, Kouji Oda, Mitsuya Hongu
Rok vydání:	2010
Předmět:	chemistry.chemical_classification chemistry.chemical_compound chemistry Stereochemistry Nucleic acid Biological activity General Medicine Deoxyuridine Alkyl
Zdroj:	ChemInform. 27
ISSN:	0931-7597
DOI:	10.1002/chin.199647235
Popis:	In an attempt to improve the effectiveness of action of 5-fluoro-2'-deoxyuridine (FUdR), various kinds of O-alkylated water-soluble analogues were synthesized. Antitumor activities against sarcoma 180 (solid) were also evaluated. Some compounds exhibited potent activities. In particular, 3'-O-p-chlorobenzyl-3-N-aminoacyloxy-methylester derivatives were effective over a very wide range of dose and gave extremely large therapeutic ratios compared with known 5-fluorouracil (5-FU) derivatives.
Databáze:	OpenAIRE
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