THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Overview

Autor: Leigh Stoddart, Henry Sackin, Stephen Tucker, Katherine Leach, Daniel Hoyer, Eric Prossnitz, Julien Hanson, Michael Spedding, Jérôme Leprince, Thiruma Arumugam, Lucie Clapp, Marta Fumagalli, Raul R Gainetdinov, David Clapham, Craig McArdle, Peter Monk, Detlev Boison, Stefan Offermanns, Susan Pyne, Gareth Sanger, Joanna Sharman, David MacEwan, Ken-ichi Inui, Cyril Goudet, Victoria Blaho, Elena Faccenda, Bernhard Bettler, Roger Summers, Nan Chiang, Gregory David Stewart, Anthony Futerman, Davide Lecca, Jörg Hamann, Simon Douglas Harding, Anthony Peter Davenport, Trent Woodruff, Mark Connor, Israel Hanukoglu, Adam Pawson, Bernard MOUILLAC, Stefania Ceruti, Nicholas Holliday, Arthur Christopoulos, Stefan Broer, Jamie Davies, Paul Chazot, Ian Kerr, Christopher Southan, William Catterall, Jyrki Kukkonen, Elvir Becirovic
Rok vydání: 2017
Předmět:
Zdroj: British Journal of Pharmacology. 174:S1-S16
ISSN: 0007-1188
DOI: 10.1111/bph.13882
Popis: The Concise Guide to PHARMACOLOGY 2017/18 is the third in this series of biennial publications. This version provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide represents approximately 400 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point-in-time record that will survive database updates. The full contents of this section can be found at http://onlinelibrary.wiley.com/doi/10.1111/bph.13882/full. In addition to this overview, in which are identified 'Other protein targets' which fall outside of the subsequent categorisation, there are eight areas of focus: G protein-coupled receptors, ligand-gated ion channels, voltage-gated ion channels, other ion channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid-2017, and supersedes data presented in the 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature Committee of the Union of Basic and Clinical Pharmacology (NC-IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate.
Databáze: OpenAIRE
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