Synthesis and Anti‐influenza Virus Activity of Novel bis(4H‐chromene‐3‐carbonitrile) Derivatives

Autor:	Amna M. Abdella, Yassmin Moatasim, Ismail A. Abdelhamid, Mohamed A. Ali, Ahmed H. M. Elwahy
Rok vydání:	2016
Předmět:	010405 organic chemistry Chemistry Organic Chemistry 010402 general chemistry 01 natural sciences Virus 0104 chemical sciences Catalysis chemistry.chemical_compound Dimedone Organic chemistry Piperidine H5N1 virus Malononitrile
Zdroj:	Journal of Heterocyclic Chemistry. 54:1854-1862
ISSN:	1943-5193 0022-152X
DOI:	10.1002/jhet.2776
Popis:	An efficient and convenient method for the synthesis of bis(4H-chromene-3-carbonitrile) derivatives by one-pot, multicomponent reaction of bis-aldehydes, malononitrile, and dimedone in the presence of a catalytic amount of piperidine is reported. Bis(2-benzylidene-1H-indene)-1,3-(2H)-dione derivatives were obtained as the main products as a result of reaction of the bis(arylidenemalononitriles) with indandione. The anti-influenza H5N1 virus activities of the newly prepared bis-chromene derivatives are also investigated.
Databáze:	OpenAIRE
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