Astrocyte Markers in the Tanycytes of the Third Brain Ventricle in Postnatal Development and Aging in Rats
| Autor: | D. E. Korzhevskii, D. A. Sufieva, O. V. Kirik |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0106 biological sciences
0303 health sciences medicine.medical_specialty Third ventricle Glial fibrillary acidic protein biology Tanycyte Connexin 01 natural sciences 03 medical and health sciences Endocrinology medicine.anatomical_structure Internal medicine Glutamine synthetase medicine biology.protein Immunohistochemistry 030304 developmental biology 010606 plant biology & botany Developmental Biology Brain Ventricle Astrocyte |
| Zdroj: | Russian Journal of Developmental Biology. 50:146-153 |
| ISSN: | 1608-3326 1062-3604 |
| Popis: | We studied the distribution of the main astrocyte markers (glutamine synthetase, glial fibrillary acidic protein, connexin 43) in the tanycytes of the third ventricle during postnatal development. Using immunohistochemical methods, we analyzed the brain sections of Wistar rats at each of the following postnatal ages: day 7 (n = 4), day 30 (n = 4), 4–6 months (n = 8), and 20 months (n = 4). It was found that the tanycytes undergo cytochemical and structural changes during postnatal development and aging. Tanycyte differentiation in the lining of the third ventricle occurs in the first postnatal week. The protein profile typical of adult rat tanycytes is formed during the first month of postnatal development. The cytochemical profile of tanycytes does not change with age, but the tanycyte processes are reorganized. The data will help to establish the role of studied proteins in the development, formation, and aging of tanycytes in the third ventricle. |
| Databáze: | OpenAIRE |
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