Particle Retention and Clearance
| Autor: | G. Patrick, V Im Hof |
|---|---|
| Rok vydání: | 1994 |
| Předmět: | |
| Zdroj: | Journal of Aerosol Medicine. 7:39-47 |
| ISSN: | 1557-9026 0894-2684 |
| DOI: | 10.1089/jam.1994.7.39 |
| Popis: | Inhaled particulate substances such as cigarette smoke, viruses, bacteria, pollen and occupational or environmental pollutants are pivotal pathogenetic factors for the development of lung disease. Nowadays an increasing number of different therapeutic aerosols are also delivered to the respiratory tract. The impact of the particles on health depends critically on their retention and clearance, which begins at the moment of their interaction with surfactant at the air-liquid interface. The major clearance mechanisms for soluble substances are absorptive processes completed within minutes, such as transepithelial diffusion and transcellular endocytosis. The most effective clearance mechanism for insoluble particles deposited in the alveolar region is phagocytosis by alveolar macrophages and subsequent transport to the mucociliary "escalator" in the conducting airways. Submicrometric particles and fibres can be translocated directly from the alveoli to the interstitial space. There is evidence that ... |
| Databáze: | OpenAIRE |
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