Novel 1, 2, 4-oxadiazoles as potent and selective histamine H3 receptor antagonists

Autor:	David I. C. Scopes, J. W. Clitherow, P. Beswick, J. Clapham, D. J. Evans, J.C. Barnes, W. J. Irving, A. G. Hayes, J.D. Brown
Rok vydání:	1996
Předmět:	Activity profile Stereochemistry Chemistry Organic Chemistry Clinical Biochemistry Antagonist Pharmaceutical Science Histamine h Biochemistry Orally active Drug Discovery Molecular Medicine Moiety Histamine H3 receptor Molecular Biology
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 6:833-838
ISSN:	0960-894X
Popis:	Replacement of the isothiourea moiety of known histamine H 3 antagonists by certain 5-membered heteroaromatic systems can give compounds with an improved activity profile. One of these, 3-[(4-chlorophenyl)methyl]-5-[2-(1H-imidazol-4-yl)ethyl] 1,2,4-oxadiazole (GR175737) is a potent, selective, orally active and centally penetrating H 3 antagonist.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::021a6f8820b7e6c9fe2cccf06616ac41 https://doi.org/10.1016/0960-894x(96)00122-9 Zobrazit plný text záznamu Full Text from ScienceDirect