Changes in composition and content of food-derived peptide in human blood after daily ingestion of collagen hydrolysate for 4 weeks
| Autor: | Mihoko Kurokawa, Yoshio Sato, Asahi Suzuki, Kenji Sato, Yasutaka Shigemura |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty food.ingredient medicine.medical_treatment Gelatin Hydrolysate 03 medical and health sciences Hydroxyproline chemistry.chemical_compound 0404 agricultural biotechnology food Internal medicine medicine Ingestion chemistry.chemical_classification 030109 nutrition & dietetics Nutrition and Dietetics Protease biology 04 agricultural and veterinary sciences 040401 food science Enzyme assay Enzyme Endocrinology chemistry biology.protein Composition (visual arts) Agronomy and Crop Science Food Science Biotechnology |
| Zdroj: | Journal of the Science of Food and Agriculture. 98:1944-1950 |
| ISSN: | 0022-5142 |
| DOI: | 10.1002/jsfa.8677 |
| Popis: | Daily ingestion of collagen hydrolysate for a long period improves skin and joint conditions. It has been speculated that the beneficial effects are exerted by food-derived hydroxyproline (Hyp) peptides, which are detected in human blood after single ingestions. In the present study, to investigate the effect of long-term ingestion of collagen hydrolysate on Hyp peptides profile in blood, the concentrations of Hyp-peptides in human blood before and after daily ingestion for a long period were examined.; Results: Hyp-peptides increased to a maximum level at 1 h after ingestion and reverted to their initial levels within 24 h during experimental period. Pro-Gly and Hyp-peptides such as Pro-Hyp-Gly, Pro-Hyp, Ile-Hyp, Leu-Hyp, Hyp-Gly, Glu-Hyp and Ala-Hyp were identified in the blood after ingestion of collagen hydrolysate at 4.5 g day-1 for 4 weeks. For the whole period, Pro-Hyp was the leading compound. The compositional rate of Hyp-Gly showed a tendency to increase, while that of Pro-Hyp tended to decrease after daily ingestion.; Conclusion: The present results indicate that daily ingestion of collagen hydrolysate for a long period can change compositional rate of Hyp peptides in human blood. This fact suggests that long-term ingestion of collagen hydrolysate might change exo- or endo-type protease activity in the digestive tract, which may consequently promote beneficial effects. © 2017 Society of Chemical Industry.; © 2017 Society of Chemical Industry. |
| Databáze: | OpenAIRE |
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