Immunohistochemical Localization of Inhibin .ALPHA.-Subunit in Two Equine Granulosa-Theca Cell Tumors
| Autor: | Wan Zhu Jin, Wendell P. Davis, Roger E. Wells, Gen Watanabe, Mohamed S. Medan, Kazuyoshi Taya |
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| Rok vydání: | 2005 |
| Předmět: |
Persistent estrus
endocrine system medicine.medical_specialty Pathology endocrine system diseases urogenital system Equine Protein subunit Theca Cell Granulosa theca cell tumor Biology female genital diseases and pregnancy complications Inhibin α Ovarian tumor Endocrinology Internal medicine medicine Immunohistochemistry Cell tumor reproductive and urinary physiology |
| Zdroj: | Journal of Equine Science. 16:45-49 |
| ISSN: | 1347-7501 1340-3516 |
| DOI: | 10.1294/jes.16.45 |
| Popis: | Granulosa-theca cell tumor (GTCT) is the most common ovarian tumor in mares. Two adult Arabian mares presented with a history of persistent estrus (No. 1) and aggressive behavior (No. 2). Large unilateral polycystic ovarian masses were identified in each mare on rectal and ultrasound examinations. The masses were surgically removed and subjected to immunohistochemical staining. The histopathologic features of both ovarian masses were consistent with GTCT. Both tumors displayed positive immunoreactivity for inhibin α-subunit, but were negative for inhibin βA and βB subunits. This report indicates that appearance of inhibin α-subunit can be used as an immunohistochemical marker in the diagnosis of GTCT in equine. |
| Databáze: | OpenAIRE |
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