Synthesis, Characterization, and in vitro Antibacterial Evaluation of Barbituric Acid Derivatives
| Autor: | Shraddha Shukla, Shaheen Fatma, Poornima Devi, Krishna Srivastava, Abha Bishnoi, Ankita Srivastava, Sunil Kumar |
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| Rok vydání: | 2019 |
| Předmět: |
Barbituric acid
biology 010405 organic chemistry Methylamine Pseudomonas aeruginosa Organic Chemistry Bacillus subtilis Carbon-13 NMR medicine.disease_cause biology.organism_classification 01 natural sciences In vitro 0104 chemical sciences chemistry.chemical_compound chemistry Staphylococcus aureus medicine Antibacterial activity Nuclear chemistry |
| Zdroj: | Russian Journal of Organic Chemistry. 55:860-865 |
| ISSN: | 1608-3393 1070-4280 |
| DOI: | 10.1134/s1070428019060174 |
| Popis: | A series of 5,5′-(arylmethylene)bis[1,3-dimethyl-6-(methylamino)pyrimidine-2,4(1H,3H)-diones] have been synthesized by 2: 1 condensation of 1,3-dimethylbarbituric acid with armatic aldehydes in the presence of methylamine. The synthesized compounds have been characterized by 1H and 13C NMR, IR, and mass spectra and tested for their in vitro antibacterial activity against Bacillus subtilis, Staphylococcus aureus, and Pseudomonas aeruginosa. Some of the compounds have shown antibacterial activity exceeding that of ampicillin used as reference drug. |
| Databáze: | OpenAIRE |
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